Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in
tumour cells. However, their effect on immune responses in the tumour microenvironment …

Breast cancer stands as a formidable global health challenge for women. While neoantigens
exhibit efficacy in activating T cells specific to cancer and instigating anti-tumor immune …

Next-generation sequencing technologies have provided insights into the biology and
mutational landscape of cancer. Here, we evaluate the relevance of cancer neoantigens in …

Simple Summary Neoantigens are novel proteins presented on the cell surface and derived
from the accumulation of somatic mutations in tumor cells. They can be recognized by the …

Tumors acquire numerous mutations during development and progression. When translated
into proteins, these mutations give rise to neoantigens that can be recognized by T cells and …

Neoantigens are mutated antigens specifically generated by cancer cells but absent in
normal cells. With high specificity and immunogenicity, neoantigens are considered as an …

ABSTRACT PURPOSE Cancer neoantigens are important targets of cancer immunotherapy.
Neoantigen vaccines have the potential to induce or enhance highly specific antitumor …

Breast cancer is both the most common type of cancer and the most frequent cause of
cancer mortality in women, mainly because of its heterogeneity and limited immunogenicity …

Somatic mutation-derived neoantigens, expressed only on tumor cells, may elicit antitumor T-
cell responses in cancer immunotherapies with minimal immune tolerance. Neoantigens …

BACKGROUND. Recent genomic and bioinformatic technological advances have made it
possible to dissect the immune response to personalized neoantigens encoded by tumor …