Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
AS Mirchandani, SJ Jenkins, CC Bain… - Nature …, 2022 - nature.com
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-
fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia …
fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia …
Toll-like receptor 3 is a therapeutic target for pulmonary hypertension
D Farkas, AAR Thompson, AR Bhagwani… - American Journal of …, 2019 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) is characterized by vascular cell
proliferation and endothelial cell apoptosis. TLR3 (Toll-like receptor 3) is a receptor for …
proliferation and endothelial cell apoptosis. TLR3 (Toll-like receptor 3) is a receptor for …
Extracellular matrix and lung inflammation
J Roman - Immunologic research, 1996 - Springer
Lung injury triggers an acute inflammatory response characterized by increased expression
and deposition of extracellular matrix (ECM) components such as fibronectin and collagen …
and deposition of extracellular matrix (ECM) components such as fibronectin and collagen …
Hyaluronan fragments/CD44 mediate oxidative stress–induced MUC5B up-regulation in airway epithelium
SM Casalino-Matsuda, ME Monzon, AJ Day… - American journal of …, 2009 - atsjournals.org
Mucus hypersecretion with elevated MUC5B mucin production is a pathologic feature in
many airway diseases associated with oxidative stress. In the present work, we evaluated …
many airway diseases associated with oxidative stress. In the present work, we evaluated …
[HTML][HTML] A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease
MY Chang, Y Tanino, V Vidova, MG Kinsella, CK Chan… - Matrix Biology, 2014 - Elsevier
The goals of this study were to characterize the changes in chondroitin sulfate proteoglycans
and hyaluronan in lungs in acute response to gram-negative bacterial infection and to …
and hyaluronan in lungs in acute response to gram-negative bacterial infection and to …
Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment
BT Garibaldi, FR D'Alessio, JR Mock… - American journal of …, 2013 - atsjournals.org
Acute lung injury (ALI) causes significant morbidity and mortality. Fibroproliferation in ALI
results in worse outcomes, but the mechanisms governing fibroproliferation remain poorly …
results in worse outcomes, but the mechanisms governing fibroproliferation remain poorly …