[HTML][HTML] Prophylactic Sublingual Immunization with Mycobacterium tuberculosis Subunit Vaccine Incorporating the Natural Killer T Cell Agonist Alpha …
Infection by Mycobacterium tuberculosis (Mtb) remains a major global concern and the
available Bacillus Calmette-Guerin (BCG) vaccine is poorly efficacious in adults. Therefore …
available Bacillus Calmette-Guerin (BCG) vaccine is poorly efficacious in adults. Therefore …
Intradermal immunization improves protective efficacy of a novel TB vaccine candidate
SL Baldwin, S Bertholet, M Kahn, I Zharkikh, GC Ireton… - Vaccine, 2009 - Elsevier
We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which
contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the …
contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the …
Protective Effect of a Lipid‐Based Preparation from Mycobacterium smegmatis in a Murine Model of Progressive Pulmonary Tuberculosis
MA García, R Borrero, ME Lanio… - BioMed research …, 2014 - Wiley Online Library
A more effective vaccine against tuberculosis (TB) is urgently needed. Based on its high
genetic homology with Mycobacterium tuberculosis (Mtb), the nonpathogenic mycobacteria …
genetic homology with Mycobacterium tuberculosis (Mtb), the nonpathogenic mycobacteria …
Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells
SL Baldwin, LK Ching, SO Pine, M Moutaftsi… - The Journal of …, 2013 - journals.aai.org
Considerable effort has been directed to develop Mycobacterium tuberculosis vaccines to
boost bacille Calmette-Guérin or for those who cannot be immunized with bacille Calmette …
boost bacille Calmette-Guérin or for those who cannot be immunized with bacille Calmette …
A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice
X Liu, Z Da, Y Wang, H Niu, R Li, H Yu, S He, M Guo… - Vaccine, 2016 - Elsevier
Tuberculosis (TB) is a serious disease around the world, and protein based subunit vaccine
is supposed to be a kind of promising novel vaccine against it. However, there is no effective …
is supposed to be a kind of promising novel vaccine against it. However, there is no effective …
[HTML][HTML] Testing the H56 vaccine delivered in 4 different adjuvants as a BCG-booster in a non-human primate model of tuberculosis
R Billeskov, EV Tan, M Cang, RM Abalos, J Burgos… - PloS one, 2016 - journals.plos.org
The search for new and improved tuberculosis (TB) vaccines has focused on IFN-γ both for
selecting antigens and for evaluating vaccine delivery strategies. The essential role of IFN-γ …
selecting antigens and for evaluating vaccine delivery strategies. The essential role of IFN-γ …
[HTML][HTML] Combinational PRR agonists in liposomal adjuvant enhances immunogenicity and protective efficacy in a tuberculosis subunit vaccine
L Hao, Y Wu, Y Zhang, Z Zhou, Q Lei, N Ullah… - Frontiers in …, 2020 - frontiersin.org
Bacillus Calmette-Guerin (BCG) is the only licensed vaccine to prevent children from
tuberculosis (TB), whereas it cannot provide effective protection for adults. Our previous …
tuberculosis (TB), whereas it cannot provide effective protection for adults. Our previous …
Novel lipopeptides of ESAT-6 induce strong protective immunity against Mycobacterium tuberculosis: Routes of immunization and TLR agonists critically impact …
Mycobacterium tuberculosis (Mtb), the bacterial cause of tuberculosis, is a leading infectious
agent worldwide. The development of a new vaccine against Mtb is essential to control …
agent worldwide. The development of a new vaccine against Mtb is essential to control …
The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening …
C Palma, E Iona, F Giannoni, M Pardini, L Brunori… - Vaccine, 2008 - Elsevier
T helper type-1 response is essential to control Mycobacterium tuberculosis (MTB) infection
but excessive antigen-mediated inflammation concurs to pathology. In mice challenged with …
but excessive antigen-mediated inflammation concurs to pathology. In mice challenged with …
[HTML][HTML] Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis …
E Eckhardt, J Schinköthe, M Gischke, J Sehl-Ewert… - Scientific Reports, 2023 - nature.com
The concept of donor-unrestricted T cells (DURTs) comprises a heterogeneity of lymphoid
cells that respond to an abundance of unconventional epitopes in a non-MHC-restricted …
cells that respond to an abundance of unconventional epitopes in a non-MHC-restricted …