Advax4 delta inulin combination adjuvant together with ECMX, a fusion construct of four protective mTB antigens, induces a potent Th1 immune response and protects …
B de Paula Oliveira Santos, MM Trentini… - Human vaccines & …, 2017 - Taylor & Francis
Tuberculosis (TB) remains a main public health concern and 10.4 million new cases
occurred in 2015 around the world. BCG is the only approved vaccine against TB, but has …
occurred in 2015 around the world. BCG is the only approved vaccine against TB, but has …
Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge
E Eckhardt, J Schinköthe, M Gischke, J Sehl-Ewert… - Scientific Reports, 2023 - nature.com
The concept of donor-unrestricted T cells (DURTs) comprises a heterogeneity of lymphoid
cells that respond to an abundance of unconventional epitopes in a non-MHC-restricted …
cells that respond to an abundance of unconventional epitopes in a non-MHC-restricted …
Pseudo-rationale design of efficient TB vaccines: lesson from the mycobacterial 27-kDa lipoprotein
AH Hovav, H Bercovier - Tuberculosis, 2006 - Elsevier
To develop or improve acellular vaccines against tuberculosis, scientists are in quest for the
most efficient Th1 antigens. Immunization of mice with the M. tuberculosis 27-kDa antigen …
most efficient Th1 antigens. Immunization of mice with the M. tuberculosis 27-kDa antigen …
Gamma Interferon and Monophosphoryl Lipid A-Trehalose Dicorynomycolate Are Efficient Adjuvants for Mycobacterium tuberculosis Multivalent Acellular Vaccine
AH Hovav, Y Fishman, H Bercovier - Infection and immunity, 2005 - Am Soc Microbiol
In this study, we examined the immunogenicity and protective efficacy of six
immunodominant Mycobacterium tuberculosis recombinant antigens (85B, 38kDa, ESAT-6 …
immunodominant Mycobacterium tuberculosis recombinant antigens (85B, 38kDa, ESAT-6 …
Liposomal delivery system/adjuvant for tuberculosis vaccine
M Moradi, F Vahedi, A Abbassioun… - Immunity …, 2023 - Wiley Online Library
As reported by the World Health Organization, about 10 million individuals were infected
with tuberculosis (TB) worldwide. Moreover, approximately 1.5 million people died of TB, of …
with tuberculosis (TB) worldwide. Moreover, approximately 1.5 million people died of TB, of …
Saponin TQL1055 adjuvant-containing vaccine confers protection upon Mycobacterium tuberculosis challenge in mice
M Ahmed, E Farris, RV Swanson, S Das… - Human Vaccines & …, 2024 - Taylor & Francis
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb),
affects the lungs of infected individuals (pulmonary TB) but can also affect other sites …
affects the lungs of infected individuals (pulmonary TB) but can also affect other sites …
Mucosal delivery switches the response to an adjuvanted tuberculosis vaccine from systemic TH1 to tissue-resident TH17 responses without impacting the protective …
MT Orr, EA Beebe, TE Hudson, D Argilla, PWD Huang… - Vaccine, 2015 - Elsevier
Pulmonary tuberculosis (TB) remains one of the leading causes of infectious disease death
despite widespread usage of the BCG vaccine. A number of new TB vaccines have moved …
despite widespread usage of the BCG vaccine. A number of new TB vaccines have moved …
Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity
J Dietrich, C Andersen, R Rappuoli… - The Journal of …, 2006 - journals.aai.org
We have examined the intranasal administration of a vaccine against Mycobacterium
tuberculosis (M. tb) consisting of the mucosal adjuvant LTK63 and the Ag Ag85B-ESAT-6 …
tuberculosis (M. tb) consisting of the mucosal adjuvant LTK63 and the Ag Ag85B-ESAT-6 …
A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium …
PK Rai, SB Chodisetti, SK Maurya, S Nadeem… - Journal of translational …, 2018 - Springer
Background The clinical trials conducted at Chingleput India suggest that BCG fails to
protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that …
protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that …
Controlled Covalent Conjugation of a Tuberculosis Subunit Antigen (ID93) to Liposome Improved In Vitro Th1-Type Cytokine Recall Responses in Human Whole …
BA Adeagbo, AO Akinlalu, T Phan, J Guderian… - ACS …, 2020 - ACS Publications
Tuberculosis (TB) remains a foremost poverty-related disease with a high rate of mortality
despite global immunization with Bacille Calmette–Guérin (BCG). Several adjuvanted …
despite global immunization with Bacille Calmette–Guérin (BCG). Several adjuvanted …