We performed the simultaneous measurement of intrinsic optical signals (IOSs) related to
metabolic activity and cellular and subcellular morphological characteristics, ie, light …

Measurement of intrinsic optical signals (IOSs) is an attractive technique for monitoring
tissue viability in brains since it enables noninvasive, real-time monitoring of morphological …

A light-scattering signal, which is sensitive to cellular/subcellular structural integrity, is a
potential indicator of brain tissue viability because metabolic energy is used in part to …

We simultaneously measured the diffuse reflectance spectra and transmittance spectra of in
vitro rat cerebral cortical tissue slices perfused with artificial cerebrospinal fluid (aCSF) in the …

The recent development of near-infrared time-and frequency-resolved tissue spectroscopy
techniques to probe tissue oxygenation and tissue oxygenation kinetics has led to the need …

Diffuse optical remission spectra from the mammalian neocortex at visible wavelengths
contain spectral features originating from the mitochondria. A new algorithm is presented …

Brain tissue is highly vulnerable to ischemia/hypoxia, and real-time monitoring of its viability
is important. By fiber-based measurements for rat brain, we previously observed a unique …

Optical techniques have gained substantial interest over the past four decades for
biomedical imaging due to their unique advantages, which may suggest their use as …

There is no reliable, simple method for delineation of ischemic regions at early time points
after ischemia. We propose that at early times after stroke, ischemic regions can be …

Optical studies of ex vivo brain slices where blood is absent show that neural activity is
accompanied by significant intrinsic optical signals (IOS) related to activity-dependent …