Background: This article discusses the putative neural mechanisms of age-related muscle
weakness within the broader context of the development of function-promoting therapies for …

In the 1990s and early 2000s, the common definition for sarcopenia was age-related loss of
skeletal muscle, and low levels of muscle mass were central to sarcopenia diagnosis. In …

Sarcopenia was originally conceptualized as the age-related loss of skeletal muscle mass.
Over the ensuing decades, the conceptual definition of sarcopenia has changed to …

Skeletal muscles constitute approximately 40% of the mass of the human body and are
composed of very long multinucleated muscle cells (myofibres) filled with specialized …

Overall lifespan and health span are dependent on maintaining neuromuscular function.
Degeneration in neural and muscular etiological factors with advancing age can result in …

Recent evidence clearly indicates that muscle weakness associated with aging is not
entirely explained by classically postulated atrophy of muscle. In this issue, which focuses …

Aging is associated with dramatic reductions in muscle strength and motor control, and
many of these agerelated changes in muscle function result from adaptations in the central …

Neuropathic, metabolic, hormonal, nutritional and immunologic factors contribute to the
development of sarcopenia. This loss of muscle mass associated with ageing, is a main …

Aging is characterized by loss of spinal motor neurons (MNs) due to apoptosis, reduced
insulin‐like growth factor I signaling, elevated amounts of circulating cytokines, and …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …