Autophagy and tumorigenesis

M Rangel, J Kong, V Bhatt, K Khayati… - The FEBS …, 2022 - Wiley Online Library
Autophagy is a catabolic process that captures cellular waste and degrades them in the
lysosome. The main functions of autophagy are quality control of cytosolic proteins and …

[HTML][HTML] Autophagy in cancer

X Zhi, Q Zhong - F1000prime reports, 2015 - ncbi.nlm.nih.gov
Autophagy is a catabolic degradation process in which cellular proteins and organelles are
engulfed by double-membrane autophagosomes and degraded in lysosomes. Autophagy …

Role of autophagy in cancer and tumor progression

B Janji, E Viry, J Baginska, K Van Moer… - Autophagy—a double …, 2013 - books.google.com
Autophagy, which is constitutively executed at basal level in all cells, promotes cellular
homeostasis by regulating organelles and proteins turnover. In tumor cells, autophagy is …

The evolving, multifaceted roles of autophagy in cancer

J Liu, J Debnath - Advances in cancer research, 2016 - Elsevier
Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in …

Molecular mechanisms of autophagy in cancer development, progression, and therapy

VAM Vitto, S Bianchin, AA Zolondick, G Pellielo… - Biomedicines, 2022 - mdpi.com
Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …

Autophagy and autophagy-related pathways in cancer

J Debnath, N Gammoh, KM Ryan - Nature reviews Molecular cell …, 2023 - nature.com
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy as a therapeutic target in cancer

N Chen, V Karantza - Cancer biology & therapy, 2011 - Taylor & Francis
Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …

The role of autophagy in cancer

N Santana-Codina, JD Mancias… - Annual Review of …, 2017 - annualreviews.org
Autophagy is a highly conserved and regulated process that targets proteins and damaged
organelles for lysosomal degradation to maintain cell metabolism, genomic integrity, and …

[HTML][HTML] Autophagy and cancer

SZ Lu, DD Harrison-Findik - World journal of biological chemistry, 2013 - ncbi.nlm.nih.gov
Autophagy is a homeostatic and evolutionarily conserved mechanism of self-digestion by
which the cells degrade and recycle long-lived proteins and excess or damaged organelles …

Autophagy: cancer's friend or foe?

SK Bhutia, S Mukhopadhyay, N Sinha, DN Das… - Advances in cancer …, 2013 - Elsevier
The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …