The originally published article contained errors in reference numbering throughout table 1
(DNA base editors and their approximate editing windows) due to the unintended …

Base editors are tools that chemically modify the nucleobases of DNA and RNA in a
programmable manner, allowing for genome, epigenome, and transcriptome editing in live …

RNA-guided programmable nucleases from CRISPR systems generate precise breaks in
DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA …

Base editors, including adenine base editors (ABEs) and cytosine base editors (CBEs),, are
widely used to induce point mutations. However, determining whether a specific nucleotide …

Advances in genetics-that began in the early 1960s-have led to continuous improvements in
our understanding of DNA's central role in the determination of biological attributes. These …

The four canonical bases that make up genomic DNA are subject to a variety of chemical
modifications in living systems. Recent years have witnessed the discovery of various new …

Base editing directly converts a target base pair into a different base pair in the genome of
living cells without introducing double-stranded DNA breaks. While cytosine base editors …

Covalent modifications of both DNA and histones act in concert to define the landscape of
our epigenome. In this review, we explore the interconnections between histone and DNA …

Prokaryotic and eukaryotic adaptive immunity differ considerably. Yet, their fundamental
mechanisms of gene editing via Cas9 and activation-induced deaminase (AID), respectively …

Genome editing has transformed the life sciences and has exciting prospects for use in
treating genetic diseases. Our laboratory developed base editing to enable precise and …