Spontaneous polymyxin-resistant mutants of Pseudomonas aeruginosa were isolated. The
mutations responsible for this phenotype were mapped to a two-component signal …

The two‐component regulatory system PhoP‐PhoQ of Pseudomonas aeruginosa regulates
resistance to cationic antimicrobial peptides, polymyxin B and aminoglycosides in response …

Antimicrobial peptides are distributed throughout the animal kingdom and are a key
component of innate immunity. Salmonella typhimurium regulates mechanisms of resistance …

Pseudomonas aeruginosa can develop resistance to polymyxin as a consequence of
mutations in the PhoPQ regulatory system, mediated by covalent lipid A modification …

Attachment of positively charged, amine-containing residues such as 4-amino-4-deoxy-l-
arabinose (l-Ara4N) and phosphoethanolamine (pEtN) to Escherichia coli and Salmonella …

As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …

Modification of lipid A with the 4-amino-4-deoxy-l-arabinose (l-Ara4N) moiety is required for
resistance to polymyxin and cationic antimicrobial peptides in Escherichia coli and …

Aminoglycoside-resistant variants of Pseudomonas aeruginosa strain PAO1 were readily
selected by culturing the organism in medium containing increasing concentrations of …

Adaptive resistance is an autoregulated phenomenon characterised by induction of
resistance in the presence of drug and reversal to the sensitive phenotype in its absence …

The emergence of multidrug resistance among Acinetobacter baumannii is leading to an
increasing dependence on the use of polymyxins as last-hope antibiotics. Here, we utilized …