Background—Dystrophin gene mutations cause 2 common muscular dystrophies,
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Both are …

Background—Becker muscular dystrophy (BMD) and X-linked dilated cardiomyopathy often
result from deletion mutations in the dystrophin gene that may lead to expression of an …

A cross-sectional study in a cohort of DNA proven carriers of Duchenne (DMD) and Becker
(BMD) muscular dystrophy was undertaken with the following objectives:(1) to estimate the …

Purpose: To review the current understanding of the pathophysiology of dilated
cardiomyopathy (DCM) in patients with Duchenne and Becker muscular dystrophies …

Objectives: Cardiac involvement has been reported in carriers of dystrophin mutations giving
rise to Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). The …

Dystrophinopathies are a group of distinct neuromuscular diseases that result from
mutations in the structural cytoskeletal Dystrophin gene. Dystrophinopathies include …

Dystrophin is a large protein serving as local scaffolding repetitively bridging cytoskeleton
and the outside of striated muscle cell. As such dystrophin is a critical brick primarily in …

Dilated cardiomyopathy (DCM) is the major indication for heart transplantation.
Approximately 30% of all DCM is thought to be inherited, while 70% is sporadic. Mutations in …

Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophies. In
addition to muscle disease, there nearly always is an associated cardiomyopathy in …

Prognosis in patients with Duchenne muscular dystrophy (DMD) is guarded, and most
deaths are due to cardiac or respiratory causes. It is unclear if some DMD gene mutations …