Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer characterized by
very poor survival outcomes. Genomic sequencing of human PDAC tissues and cell lines …

The epithelial–mesenchymal transition (EMT) plays a crucial role in pancreatic ductal
adenocarcinoma (PDAC) development and progression. TWIST activated by intra-tumoral …

Hepatocellular carcinoma (HCC) is a top global cancer health concern due to its high rate of
mortality and increasing incidence. HCC lethality is largely attributable to its poor response …

Pancreatic cancer is the 4th most common cause of cancer deaths in this country. Close to
50,000 deaths occur every year. This is due to the fact that most patients are not diagnosed …

Twist1, a basic helix-loop-helix transcription factor, plays a key role during development and
is a master regulator of the epithelial–mesenchymal transition (EMT) that promotes cancer …

Twist1 is a highly conserved basic helix-loophelix transcription factor, and has been shown
to play an important role in carcinogenesis of many tumors including colorectal cancer …

Cancer-associated fibroblasts (CAFs) play important roles in cancer progression. Twist1 was
recently reported to be a key regulator of CAFs in gastric cancer, but its role in other types of …

Metastatic breast tumor cells display an epithelial–mesenchymal transition (EMT) that
increases cell motility, invasion, and dissemination. Although the transcription factor Twist1 …

As reported, the CC chemokine receptor 7 (CCR7) trigger a series of signaling cascades in
the epithelial-mesenchymal transition (EMT) of some malignancies. Meanwhile, Twist …

Dissemination is an essential early step in metastasis but its molecular basis remains
incompletely understood. To define the essential targetable effectors of this process, we …