[HTML][HTML] Protein kinase Cα–mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it
R Tedja, CM Roberts, AB Alvero, C Cardenas… - Journal of Biological …, 2019 - ASBMB
Twist1 is a basic helix-loop-helix transcription factor that plays a key role in embryonic
development, and its expression is down-regulated in adult cells. However, Twist1 is highly …
development, and its expression is down-regulated in adult cells. However, Twist1 is highly …
Twist1 is a key regulator of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAF) are key contributors to malignant progression, but their
critical regulators remain largely unknown. In this study, we examined the role of Twist1, a …
critical regulators remain largely unknown. In this study, we examined the role of Twist1, a …
The Aurora-A–Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma
J Wang, K Nikhil, K Viccaro, L Chang… - Journal of cell …, 2017 - journals.biologists.com
We uncovered a crucial role for the Aurora kinase A (AURKA)–Twist1 axis in promoting
epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer …
epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer …
[HTML][HTML] Genomic pathways modulated by Twist in breast cancer
F Vesuna, Y Bergman, V Raman - BMC cancer, 2017 - Springer
Background The basic helix-loop-helix transcription factor TWIST1 (Twist) is involved in
embryonic cell lineage determination and mesodermal differentiation. There is evidence to …
embryonic cell lineage determination and mesodermal differentiation. There is evidence to …
TWIST1 is required for suppression of apoptosis in oncogene driven non-small cell lung carcinoma
ZA Yochum, JA Cades, L Mazacurati, S Chatley… - Cancer Research, 2015 - AACR
A large fraction of non-small cell lung cancers (NSCLC) are dependent on defined
oncogenic driver mutations. The most common oncogene driver mutation is mutant KRAS for …
oncogenic driver mutations. The most common oncogene driver mutation is mutant KRAS for …
[引用][C] Leads to Activation of Oncogene-Induced TWIST1 Inhibition of
TF Burns, I Dobromilskaya, SC Murphy
[HTML][HTML] TWIST1 is a prognostic factor for neoadjuvant chemotherapy for patients with resectable pancreatic cancer: a preliminary study
S Fujiwara, Y Saiki, S Fukushige, M Yamanaka… - Surgery Today, 2023 - Springer
Recent advances in the development of chemotherapies have helped improve the
prognosis of pancreatic ductal adenocarcinoma (PDAC). However, predicting factors for the …
prognosis of pancreatic ductal adenocarcinoma (PDAC). However, predicting factors for the …
[HTML][HTML] Twist promotes invasion and cisplatin resistance in pancreatic cancer cells through growth differentiation factor 15
H Ji, HW Lu, YM Li, L Lu, JL Wang… - Molecular …, 2015 - spandidos-publications.com
Pancreatic cancer (PC) is an aggressive and devastating disease with a poor prognosis.
Cisplatin, a commonly used chemotherapeutic agent for solid tumors, is effective as a single …
Cisplatin, a commonly used chemotherapeutic agent for solid tumors, is effective as a single …
[HTML][HTML] Twist promotes angiogenesis in pancreatic cancer by targeting miR-497/VEGFA axis
A Liu, C Huang, X Cai, J Xu, D Yang - Oncotarget, 2016 - ncbi.nlm.nih.gov
Angiogenesis is a critical step in the growth and dissemination of malignant diseases,
including pancreatic cancer. Twist has been shown to stimulate angiogenesis in the tumor …
including pancreatic cancer. Twist has been shown to stimulate angiogenesis in the tumor …
Twist1 and AP-1 cooperatively upregulate integrin α5 expression to induce invasion and the epithelial–mesenchymal transition
EH Nam, Y Lee, B Moon, JW Lee, S Kim - Carcinogenesis, 2015 - academic.oup.com
Epithelial–mesenchymal transition (EMT) is an important process implicated in tumor
invasion and metastasis. Twist1 is a transcription factor that induces EMT, including E …
invasion and metastasis. Twist1 is a transcription factor that induces EMT, including E …