Synthesis of 4‐alkyl‐3‐pyridinols from 3‐benzyloxypyridine

DL Comins, ED Stroud - Journal of heterocyclic chemistry, 1985 - Wiley Online Library
The addition of Grignard reagents to the 1‐phenoxycarbonyl salt of 3‐benzyloxypyridine and
a catalytic amount of cuprous iodide afforded 4‐alkyl‐3‐benzyloxy‐1‐phenoxycarbonyl‐1, 4 …

A new preparation of N-Alkyl-2 (1H)-pyridones from 2-glycidoxypyridines

JC Schmidhauser, KL Longley - Tetrahedron letters, 1991 - Elsevier
Abstract N-Alkyl-2 (1H)-pyridones are prepared in high yield by the reaction of 2-
glycidoxypyridines with carboxylic acids, phenols or thiophenols. These reactions proceed …

Regioselective synthesis of 4-alkylpyridines via 1, 4-dihydropyridine derivatives from pyridine

K Akiba, Y Iseki, M Wada - Tetrahedron Letters, 1982 - Elsevier
Abstract N-Ethoxycarbonylpyridinium chloride (1) reacted with RCu· BF 3 at 4-position with
almost complete regioselectivity (better than 99%) to afford the corresponding 1, 4 …

Synthesis of substituted 4-pyridones and 4-aminopyridinium salts via a one-pot pyridine synthesis

H Andersson, S Das, M Gustafsson, R Olsson… - Tetrahedron …, 2010 - Elsevier
Synthesis of substituted 4-pyridones and 4-aminopyridinium salts via a one-pot pyridine
synthesis - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

A convenient method for the regioselective synthesis of 4-alkyl (aryl) pyridines using pyridinium salts.

K Akiba, Y Iseki, M Wada - Bulletin of the Chemical Society of Japan, 1984 - jlc.jst.go.jp
RCu· BF 3 reacted with 1-ethoxycarbonylpyridinium chloride at the 4-position with almost
complete regio-selectivity (> 99%) to afford the corresponding 1, 4-dihydropyridine …

Functionalization of substituted 2(1H)‐pyridones. V. The synthesis of 1,2‐dihydro‐2‐oxo‐3,5‐pyridinedicarboxylic acid derivatives through a novel dianion route

JM Domagala - Journal of heterocyclic chemistry, 1984 - Wiley Online Library
A new pyridone dianion was prepared by halogen‐metal exchange from 5‐bromo‐1, 2‐
dihydro‐2‐oxo‐3‐pyrid‐inecarboxylic acid, t‐butyl ester and two equivalents of n …

Carboxylate derivatives of oligopyridines

RA Fallahpour - Synthesis, 2000 - thieme-connect.com
The key compound ethyl 2, 6-dibromopyridine-4-carboxylate was prepared in two steps
starting from the commercially available citrazinic acid. By using the Stille coupling reaction …

[PDF][PDF] Synthesis of 3-halo-and 3-formyl-4-alkylpyridines

DL Comins, RK Smith, ED Stroud - Heterocycles, 1984 - triggered.stanford.clockss.org
-- In the presence of a catalytic amount of cuprous iodide, the addition of Grignard reagents
to the 1-phenoxycarbonyl salts of 3-halopyridines gives 4-alkyl-3-halo-l-phenoxycarbonyl-l …

Synthesis of 3, 5-diacyl-4-phenyl-1, 4-dihydropyridines

ML Bennasar, C Juan, J Bosch - Tetrahedron letters, 1998 - Elsevier
3, 5-Diacyl-4-phenyl-1, 4-dihydropyridines have been synthesized via a regio-and
chemoselective addition of Ph2Cu (CN) Li2 to β-substituted N-alkylpyridinium salts, followed …

Facile synthesis of 4-substituted pyridines using Grignard reagents

K Akiba, Y Iseki, M Wada - Tetrahedron Letters, 1982 - Elsevier
Nt-Butyldimethylsilylpyridinium triflate 2 reacted with Grignard reagents at 4-position with
almost complete regioselectivity (> 99%) to afford the corresponding 1, 4-dihydropyridine …