Transcription factors (TFs) represent the most commonly deregulated DNA-binding class of
proteins associated with multiple human cancers. They can act as transcriptional activators …

The tremendous advances achieved in the understanding of cancer biology have delivered
unprecedented progress in molecularly targeted cancer therapy in the past decade. The fast …

Post-translational modifications (PTMs) have been reported to play pivotal roles in
numerous cellular biochemical and physiological processes. Multiple PTMs can influence …

Mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cellular growth,
development, survival, and metabolism through integration of diverse extracellular and …

Protein post-translational modification (PTM) is a regulatory mechanism for protein activity
modulation, localization, expression, and interactions with other cellular molecules. It …

There is currently a high level of interest in signalling through the mammalian target of
rapamycin (mTOR). This reflects both its key role in many cell functions and its involvement …

While improved tumor treatment has significantly reduced the overall mortality rates,
invasive progression including recurrence, therapy resistance and metastasis contributes to …

Simple Summary The protein translation machinery, of which tRNA is an essential part, is
critical in controlling the growth of tumor cells. The development of cancer is also influenced …

Modern drug design aims to discover novel lead compounds with attractable chemical
profiles to enable further exploration of the intersection of chemical space and biological …

Highlights•Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase
involved in metabolism regulation.•Increasing evidence reports that mTOR dysregulation is …