Malignant tumors remain the health problem of highest concern among people worldwide
due to its high mortality and recurrence. Lung, gastric, liver, colon, and breast cancers are …

The appreciation that cancer growth is promoted by a dynamic tumor microenvironment
(TME) has spawned novel approaches to cancer treatment. New therapies include agents …

Translational research is about transforming progress in basic research into products that
benefit patients. Here I discuss some of the key obstacles to effective translational research …

Molecular alterations in cancer genes and associated signaling pathways are used to inform
new treatments for precision medicine in cancer. Small molecule inhibitors and monoclonal …

Evolutionarily conserved and pleiotropic, the translationally controlled tumor protein (TCTP)
is a housekeeping protein present in eukaryotic organisms. It plays an important role in …

As ovarian tumors progress, they undergo a process of dedifferentiation, allowing adaptive
changes in growth and morphology that promote metastasis and chemoresistance. Herein …

Misregulated transcription factors play prominent roles in human disease, but their dynamic
protein-protein interaction network has long made the goal of transcription-targeted …

Transcriptional reprogramming contributes to the progression and recurrence of cancer.
However, the poorly elucidated mechanisms of transcriptional reprogramming in tumors …

Transcription factors (TFs) are responsible for decoding and expressing the information
stored in the genome, which dictates cellular function. Creating artificial transcription factors …

Cancer cells are characterized by the presence of multiple genetic alterations and the
accumulation of these alterations drives the progression of normal cells to invasive cancer …