ABCD3 is one of three ATP-binding cassette (ABC) transporters present in the peroxisomal
membrane catalyzing ATP-dependent transport of substrates for metabolic pathways …

Peroxisomes metabolize a specific subset of fatty acids, which include dicarboxylic fatty
acids (DCAs) generated by ω‐oxidation. Data obtained in vitro suggest that the peroxisomal …

ATP-binding cassette (ABC) transporters facilitate unidirectional translocation of chemically
diverse substances, ranging from peptides to lipids, across cell or organelle membranes. In …

ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of
conserved proteins from bacteria to mammals. In humans, three members of this family are …

Peroxisomes play a major role in human cellular lipid metabolism, including fatty acid β-
oxidation. Free fatty acids (FFAs) can enter peroxisomes through passive diffusion or by …

Peroxisomes are indispensable organelles in higher eukaryotes. They are essential for a
number of important metabolic pathways, including fatty acid α‐and β‐oxidation, and …

Peroxisomes are essential organelles exerting key functions in fatty acid metabolism such
as the degradation of very long-chain fatty acids (VLCFAs). VLCFAs accumulate in X …

Peroxisomes play an essential role in the β-oxidation of dicarboxylic acids (DCAs), which
are metabolites formed upon ω-oxidation of fatty acids. Genetic evidence linking transporters …

Peroxisomes play a major role in human cellular lipid metabolism, including the β‐oxidation
of fatty acids. The most frequent peroxisomal disorder is X‐linked adrenoleukodystrophy (X …

The gene mutated in X-linked adrenoleukodystrophy (X-ALD) codes for the HsABCD1
protein, also named ALDP, which is a member of the superfamily of ATP-binding cassette …