Adenosine and ATP, via their specific P1 and P2 receptors, modulate a wide variety of
cellular and tissue functions, playing a neuroprotective or neurodegenerative role in brain …

In the rat brain, a heteromeric association between adenosine A1 and purinergic P2Y1
receptors has been demonstrated. It is suggested that this association plays an important …

Background Purines such as adenosine and ATP are now generally recognized as the
regulators of many physiological functions, such as neurotransmission, pain, cardiac …

Adenosine and ATP modulate cellular and tissue functions via specific P1 and P2 receptors,
respectively. Although, in general, adenosine inhibits excitability and ATP functions as an …

Adenosine and its endogenous precursor ATP are main components of the purinergic
system that modulates cellular and tissue functions via specific adenosine and ATP …

Adenosine and ATP/UTP are main components of the purinergic system that modulate
cellular and tissue functions via specific adenosine and P2 receptors, respectively. Here, we …

There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …

Purinergic signalling plays a major role in intercellular communication between neurons and
glial cells. Glial cells express metabotropic receptors for ATP and adenosine, the latter being …

Electrophysiological recordings were used to investigate the effects of ATP analogues on θ-
burst-induced long-term potentiation (LTP) in rat hippocampal slices. α, β-Methylene ATP (α …

It is now well accepted that G protein-coupled receptors (GPCRs) can be directly associated,
as either homo-or hetero-oligomers, to alter their functions. G protein-coupled purinergic …