Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be
synergistically augmented with immunostimulatory mAbs to act both on irradiated tumor …

Radiation therapy (RT) in some cases results in a systemic anticancer response known as
the abscopal effect. Multiple hypotheses support the role of immune activation initiated by …

The clearance of nonirradiated tumors after localized radiation therapy is known as the
abscopal effect. Activation of an antitumor immune response has been proposed as a …

Ionizing radiation has historically been used to treat cancer by killing tumour cells, in
particular by inducing DNA damage. This view of radiotherapy (RT) as a simple cytotoxic …

In cancer patients undergoing radiation therapy, the beneficial effects of radiation can
extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors …

An “abscopal” effect occurs when localized irradiation perturbs the organism as a whole,
with consequences that can be either beneficial or detrimental. Mechanistic explanations of …

Abscopal effect is a rare phenomenon characterized by tumor regression of untreated
metastatic lesions after a local therapy (eg, radiotherapy). We studied the probability of …

The immunostimulatory properties of radiation therapy (RT) have recently generated
widespread interest due to preclinical and clinical evidence that tumor-localized RT can …

Background Radiotherapy (RT) has been shown to stimulate an antitumor immune response
in irradiated tumors as well as unirradiated distant sites (abscopal effect). Previous studies …

Even though there is extensive research carried out in radiation oncology, most of the
clinical studies focus on the effects of radiation on the local tumor tissue and deal with …