Cancer comprises a collection of highly proliferative and heterogeneous cells growing within
an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly …

The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …

Organoids are in vitro–cultured three-dimensional structures that recapitulate key aspects of
in vivo organs. They can be established from pluripotent stem cells and from adult stem …

Organoids are established through in vitro 3D culture, and they can mimic the structure and
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …

Abstract Three-dimensional (3D) cultures use the property of some cells to self-organize in
matrices and generate structures that can be programmed to represent an organ or a …

Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Organoids are a class of multicellular structures with the capability of self-organizing and the
characteristic of original tissues, they are generated from stem cells in 3D culture in vitro …

Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …

Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …