[HTML][HTML] Current concepts in tumour-derived organoids
RJ Porter, GI Murray, MH McLean - British journal of cancer, 2020 - nature.com
Cancer comprises a collection of highly proliferative and heterogeneous cells growing within
an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly …
an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly …
Organoids in cancer research
J Drost, H Clevers - Nature Reviews Cancer, 2018 - nature.com
The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …
new avenues for the development of novel, more physiological human cancer models. Such …
Human organoids: tools for understanding biology and treating diseases
F Schutgens, H Clevers - Annual Review of Pathology …, 2020 - annualreviews.org
Organoids are in vitro–cultured three-dimensional structures that recapitulate key aspects of
in vivo organs. They can be established from pluripotent stem cells and from adult stem …
in vivo organs. They can be established from pluripotent stem cells and from adult stem …
[HTML][HTML] The role of organoids in cancer research
Z Fang, P Li, F Du, L Shang, L Li - Experimental Hematology & Oncology, 2023 - Springer
Organoids are established through in vitro 3D culture, and they can mimic the structure and
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …
Concise review: current status of three-dimensional organoids as preclinical models
Abstract Three-dimensional (3D) cultures use the property of some cells to self-organize in
matrices and generate structures that can be programmed to represent an organ or a …
matrices and generate structures that can be programmed to represent an organ or a …
[HTML][HTML] Organoids
Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …
aspects of the complex structure and function of the corresponding in vivo tissue. They can …
[HTML][HTML] Organoids: opportunities and challenges of cancer therapy
Organoids are a class of multicellular structures with the capability of self-organizing and the
characteristic of original tissues, they are generated from stem cells in 3D culture in vitro …
characteristic of original tissues, they are generated from stem cells in 3D culture in vitro …
Applications of organoids for cancer biology and precision medicine
YH Lo, K Karlsson, CJ Kuo - Nature Cancer, 2020 - nature.com
Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …
of origin more accurately than classical culture approaches. Seminal characteristics of these …
Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy
J Qu, FS Kalyani, L Liu, T Cheng… - Cancer …, 2021 - Wiley Online Library
Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …
[HTML][HTML] The use of stem cell-derived organoids in disease modeling: an update
Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …
during the past decade. They are three-dimensional in vitro culturing models that originate …