Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

High heterogeneity of macrophage is associated with its functions in polarization to different
functional phenotypes depending on environmental cues. Macrophages remain in balanced …

Macrophages are influential members of the innate immune system that can be reversibly
polarized by different microenvironment signals. Cell polarization leads to a wide range of …

Macrophages make up a crucial aspect of the immune system, carrying out a variety of
functions ranging from clearing cellular debris to their well-recognized roles as innate …

Macrophages are a type of functionally plastic cells that can create a pro-/anti-inflammatory
microenvironment for organs by producing different kinds of cytokines, chemokines, and …

Macrophages play an important role in a wide variety of physiologic and pathologic
processes. Plasticity and functional polarization are hallmarks of macrophages …

Background: Macrophages (Mφs) participate in wound healing by coordinating inflammatory
and angiogenic processes. Mφs respond to environmental cues by adopting either …

Highlights•Macrophage activation is best described by a multi-dimensional model.•Targeting
macrophages specifically requires a multi-modal approach.•Macrophage reprogramming …

Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly,
the dysfunction of macrophages is involved in the occurrence and progression of various …

Macrophages, as crucial cellular components of innate immunity, are characterized by
possessing high plasticity and an abnormal ability to differentiate in response to numerous …