Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes
simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using …

Mechanical hypersensitivity is a debilitating symptom for millions of chronic pain patients. It
exists in distinct forms, including brush-evoked dynamic and filament-evoked punctate …

The somatosensory system decodes a wide range of tactile stimuli and thus endows us with
a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback …

Pain and itch are two closely related but essentially distinct sensations that elicit different
behavioral responses. However, it remains mysterious how pain and itch information is …

Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

Chronic pain presents a major unmet clinical problem. The development of more effective
treatments is hindered by our limited understanding of the neuronal circuits underlying …

Emotionally‐laden tactile stimulation—such as a caress on the skin or the feel of velvet—
may represent a functionally distinct domain of touch, underpinned by specific cortical …

The canonical view is that touch is signaled by fast-conducting, thickly myelinated afferents,
whereas pain is signaled by slow-conducting, thinly myelinated (“fast” pain) or unmyelinated …

The sense of touch is fundamental as it provides vital, moment-to-moment information about
the nature of our physical environment. Primary sensory neurons provide the basis for this …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …