The purine analog xanthine oxidase (XO) inhibitors (XOIs), allopurinol and oxypurinol, have
been reported to protect against heart failure secondary to myocardial infarction or rapid …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …

Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …

We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects
on both ventricular and vascular performance in evolving heart failure (HF), thereby …

After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …

We investigated whether xanthine oxidase inhibition with febuxostat enhances left
ventricular (LV) function and improves myocardial high energy phosphates (HEP) in dogs …