Gap junctions are a unique type of intercellular channels that connect the cytoplasm of
adjoining cells. Each gap junction channel is comprised of two hemichannels or connexons …

Tumour development is a process resulting from the disturbance of various cellular functions
including cell proliferation, adhesion and motility. While the role of these cell parameters in …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …

Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …

Evidence is accumulating that some forms of cell death, like apoptosis, are not only
governed by the complex interplay between extracellular and intracellular signals but are …

If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it
appeared useful to work out a theory explaining the complexity of this disease. More than …

Intercellular communication can occur through gap junction channels, which are comprised
of connexin proteins. Therefore, levels of connexins can directly correlate with gap junctional …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …