[HTML][HTML] Connexins and pannexins: Important players in tumorigenesis, metastasis and potential therapeutics
Since their characterization more than five decades ago, gap junctions and their structural
proteins—the connexins—have been associated with cancer cell growth. During that period …
proteins—the connexins—have been associated with cancer cell growth. During that period …
[HTML][HTML] Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?
A Salameh, S Dhein - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2005 - Elsevier
Intercellular communication in many organs is maintained via intercellular gap junction
channels composed of connexins, a large protein family with a number of isoforms. This gap …
channels composed of connexins, a large protein family with a number of isoforms. This gap …
Gap junctions as targets for cancer chemoprevention and chemotherapy
JE Trosko, RJ Ruch - Current Drug Targets, 2002 - ingentaconnect.com
The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
[HTML][HTML] Connexins in migration during development and cancer
Connexins, the gap junction proteins, through their multitude of actions are implicated in a
variety of cell processes during animal development and cancer. They allow direct or …
variety of cell processes during animal development and cancer. They allow direct or …
Biological role of connexin intercellular channels and hemichannels
R Kar, N Batra, MA Riquelme, JX Jiang - Archives of biochemistry and …, 2012 - Elsevier
Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …
connexins are transmembrane conduits for the exchange of small molecules and ions …
[HTML][HTML] Regulation of connexin expression
M Oyamada, Y Oyamada, T Takamatsu - Biochimica et Biophysica Acta …, 2005 - Elsevier
Gap junctions contain cell–cell communicating channels that consist of multimeric proteins
called connexins and mediate the exchange of low-molecular-weight metabolites and ions …
called connexins and mediate the exchange of low-molecular-weight metabolites and ions …
Endogenous and exogenous modulation of gap junctional intercellular communication: toxicological and pharmacological implications
JE Trosko, BV Madhukar, CC Chang - Life sciences, 1993 - Elsevier
During the evolution of single-celled organisms to multicellular metazoans, a family of highly
conserved genes coding for proteins (connexins), which as hexameric units (connexons) …
conserved genes coding for proteins (connexins), which as hexameric units (connexons) …
Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo
VA Krutovskikh, SM Troyanovsky, C Piccoli, H Tsuda… - Oncogene, 2000 - nature.com
There is a large body of evidence suggesting the connexin gap junction proteins appear to
act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main …
act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main …
Connexins and cell signaling in development and disease
CJ Wei, X Xu, CW Lo - Annu. Rev. Cell Dev. Biol., 2004 - annualreviews.org
▪ Abstract Gap junctions contain hydrophilic membrane channels that allow direct
communication between neighboring cells through the diffusion of ions, metabolites, and …
communication between neighboring cells through the diffusion of ions, metabolites, and …