AKI with incomplete epithelial repair is a major contributor to CKD characterized by
tubulointerstitial fibrosis. Injury–induced epithelial secretion of profibrotic factors is …

Injury to the adult kidney induces a number of developmental genes thought to regulate
repair, including Wnt4. During kidney development, early nephron precursors and medullary …

Wnts compose a family of signaling proteins that play an essential role in kidney
development, but their expression in adult kidney is thought to be silenced. Here, we …

Wnt/β-catenin signaling is extremely important for proper kidney development. This pathway
is also upregulated in injured renal tubular epithelia, both in acute kidney injury and chronic …

The Wnt/β-catenin pathway is crucial in normal development and throughout life, but
aberrant activation of this pathway has been linked to kidney fibrosis, although the …

Cell-cell communication via Wnt ligands is necessary in regulating embryonic development
and has been implicated in CKD. Because Wnt ligands are ubiquitously expressed, the …

Tubulointerstitial fibrosis, tubular atrophy, and peritubular capillary rarefaction are major
hallmarks of chronic kidney disease. The tubulointerstitium consists of multiple cell …

Wnt/β-catenin signaling is an evolutionarily conserved, highly complex, key developmental
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …

Background Kidney injury is characterized by persisting inflammation and fibrosis, yet
mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined …

We have examined the pathogenic role of increased complement expression and activation
during kidney fibrosis. Here, we show that PDGFRβ-positive pericytes isolated from mice …