Replication of chronic abnormal cartilage loading by medial meniscus destabilization for modeling osteoarthritis in the rabbit knee in vivo

M Arunakul, Y Tochigi, JE Goetz… - Journal of …, 2013 - Wiley Online Library
Medial meniscus destabilization (MMD) is a surgical insult technique for modeling
osteoarthritis (OA) by replicating chronic abnormal cartilage loading in animal joints in vivo …

Transection of the medial meniscus anterior horn results in cartilage degeneration and meniscus remodeling in a large animal model

S Bansal, LM Miller, JM Patel… - Journal of …, 2020 - Wiley Online Library
The meniscus plays a central load‐bearing role in the knee joint. Unfortunately, meniscus
injury is common and can lead to joint degeneration and osteoarthritis (OA). In small animal …

[HTML][HTML] The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse

SS Glasson, TJ Blanchet, EA Morris - Osteoarthritis and cartilage, 2007 - Elsevier
OBJECTIVE: To evaluate anterior cruciate ligament transection (ACLT) and destabilization
of the medial meniscus (DMM) surgical instability models of osteoarthritis (OA) in the …

Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse

MA David, MK Smith, RN Pilachowski… - Journal of …, 2017 - Wiley Online Library
Post‐traumatic osteoarthritis (PTOA) is an accelerated form of osteoarthritic cartilage
degeneration affecting approximately 20–50% of patients experiencing joint injury. Currently …

[HTML][HTML] Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model

H Iijima, T Aoyama, A Ito, J Tajino, M Nagai… - Osteoarthritis and …, 2014 - Elsevier
Objective This study aimed to investigate subchondral bone changes using micro-computed
tomography (micro-CT) and regional differences in articular cartilage degeneration, focusing …

[HTML][HTML] Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity

JP Moodie, KS Stok, R Müller, TL Vincent… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Alterations in joint mechanics can cause osteoarthritis, which results in
degeneration of both cartilage and bone tissue. The objective of this work is to measure …

Osteoarthritis mouse model of destabilization of the medial meniscus

A Sophocleous, C Huesa - Bone Research Protocols, 2019 - Springer
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Quantitative histological grading methods to assess subchondral bone and synovium changes subsequent to medial meniscus transection in the rat

HE Kloefkorn, KD Allen - Connective tissue research, 2017 - Taylor & Francis
ABSTRACT Aim of the Study: The importance of the medial meniscus to knee health is
demonstrated by studies which show meniscus injuries significantly increase the likelihood …

Chondropathy after meniscal tear or partial meniscectomy in a canine model

DJ Wyland, F Guilak, DM Elliott… - Journal of …, 2002 - Wiley Online Library
A primary goal in considering treatment for meniscal injuries is the preservation of the health
of the articular cartilage. However, the chondroprotective effects of various techniques for …

[HTML][HTML] Modelling osteoarthritis in mice via surgical destabilization of the medial meniscus with or without a stereomicroscope

W Hu, J Lin, J Wei, Y Yang, K Fu, T Zhu… - Bone & Joint …, 2022 - boneandjoint.org.uk
Aims To evaluate inducing osteoarthritis (OA) by surgical destabilization of the medial
meniscus (DMM) in mice with and without a stereomicroscope. Methods Based on sample …