Pathway crosstalk analysis in prostate cancer based on protein-protein network data.

HY Li, N Jin, YP Han, XF Jin - Neoplasma, 2017 - europepmc.org
Prostate cancer (PCa) is one of the major leading cause in men and no effective biomarkers
or therapy have been approved for it to date. This study aimed to explore the molecular …

Bioinformatics analysis based on multiple databases identifies hub genes associated with hepatocellular carcinoma

L Zeng, X Fan, X Wang, H Deng, K Zhang… - Current …, 2019 - ingentaconnect.com
Background: Hepatocellular carcinoma (HCC) is the most common liver cancer and the
mechanisms of hepatocarcinogenesis remain elusive. Objective: This study aims to mine …

[HTML][HTML] Identification and Validation of Hub Genes Associated With Hepatocellular Carcinoma Via Integrated Bioinformatics Analysis

S Wang, Z Song, B Tan, J Zhang, J Zhang… - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver, with high
morbidity and mortality, yet its molecular mechanisms of tumorigenesis are still unclear. In …

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

L Gong, D Zhang, Y Lei, Y Qian, X Tan… - Cancer Medicine, 2018 - Wiley Online Library
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a
transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC). GWAS …

Overexpression of topoisomerase 2-alpha confers a poor prognosis in pancreatic adenocarcinoma identified by co-expression analysis

Z Zhou, S Liu, M Zhang, R Zhou, J Liu, Y Chang… - Digestive diseases and …, 2017 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of
human cancer-related death in the developed countries. Its progression and prognosis are …

[HTML][HTML] Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics …

J Ding, Y Liu, Y Lai - PeerJ, 2020 - peerj.com
Background Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant neoplasm. It is
necessary to improve the understanding of the underlying molecular mechanisms and …

[HTML][HTML] The identification of potential biomarkers and biological pathways in prostate cancer

Z Song, Y Huang, Y Zhao, H Ruan, H Yang… - Journal of …, 2019 - ncbi.nlm.nih.gov
Purpose: The present study aims to explore the potential mechanisms contributing to
prostate cancer (PCa), screen the hub genes, and identify potential biomarkers and …

[HTML][HTML] GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments

Y Feng, Y Jiang, F Hao - Journal of translational medicine, 2021 - Springer
Background Pancreatic cancer is one of the most serious digestive malignancies. At present,
there is an extreme lack of effective strategies in clinical treatment. The purpose of this study …

[HTML][HTML] Gene expression characteristics of tumor and adjacent non-tumor tissues of pancreatic ductal adenocarcinoma (PDAC) in-silico

E Güven - Iranian Journal of Biotechnology, 2022 - ncbi.nlm.nih.gov
Background: One of the deadliest and most prevalent cancer is pancreatic ductal
adenocarcinoma (PDAC). Microarray has become an important tool in the research of PDAC …

[HTML][HTML] Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma

J Li, W Tan, L Peng, J Zhang, X Huang, Q Cui… - Cancer …, 2018 - Springer
Background Pancreatic duct adenocarcinoma (PDAC) remains a major health problem
because conventional cancer treatments are relatively ineffective against it. Microarray …