[HTML][HTML] Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases
X Cheng, RM Blumenthal - Current opinion in structural biology, 2022 - Elsevier
Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG
dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and …
dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and …
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
SJ Kim, H Zhao, S Hardikar, AK Singh… - Blood, The Journal …, 2013 - ashpublications.org
Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …
frequently in acute myeloid leukemia and other hematological malignancies, with the …
The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity
TV Nguyen, S Yao, Y Wang, A Rolfe, A Selvaraj… - Journal of Biological …, 2019 - ASBMB
DNMT3A (DNA methyltransferase 3A) is a de novo DNA methyltransferase responsible for
establishing CpG methylation patterns within the genome. DNMT3A activity is essential for …
establishing CpG methylation patterns within the genome. DNMT3A activity is essential for …
Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation
C Holz-Schietinger, DM Matje, MF Harrison… - Journal of Biological …, 2011 - ASBMB
DNMT3A is one of two human de novo DNA methyltransferases essential for regulating
gene expression through cellular development and differentiation. Here we describe the …
gene expression through cellular development and differentiation. Here we describe the …
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation
Abstract DNA methyltransferase DNMT3A is essential for establishment of mammalian DNA
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity
Y Li, HJ Abel, M Cai, TA LaValle, T Yin, NM Helton… - Science …, 2024 - science.org
Here, we characterize the DNA methylation phenotypes of bone marrow cells from mice with
hematopoietic deficiency of Dnmt3a or Dnmt3b (or both enzymes) or expressing the …
hematopoietic deficiency of Dnmt3a or Dnmt3b (or both enzymes) or expressing the …
Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein …
JE Sandoval, YH Huang, A Muise, MA Goodell… - Journal of Biological …, 2019 - ASBMB
Eukaryotic DNA methylation prevents genomic instability by regulating the expression of
oncogenes and tumor-suppressor genes. The negative effects of dysregulated DNA …
oncogenes and tumor-suppressor genes. The negative effects of dysregulated DNA …
DNA methyltransferases in hematological malignancies
DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …
[HTML][HTML] Loss of de novo DNA methyltransferase DNMT3A impacts alternative splicing in hematopoietic stem cells
R Ramabadran, J Wang, A Guzman, SM Cullen… - Blood, 2017 - Elsevier
DNMT3A is a de novo DNA methyltransferase that is crucial to the maintenance of normal
hematopoiesis. DNMT3A is frequently mutated in hematopoietic diseases, with mutations …
hematopoiesis. DNMT3A is frequently mutated in hematopoietic diseases, with mutations …
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
Abstract DNA methyltransferases DNMT3A-and DNMT3B-mediated DNA methylation
critically regulate epigenomic and transcriptomic patterning during development. The …
critically regulate epigenomic and transcriptomic patterning during development. The …