Background Cold static storage (CS) is a proven preservation method for heart
transplantion, yet early postoperative graft dysfunction remains prevalent, so continuous …

BACKGROUND: By minimizing tissue ischemia, continuous perfusion (CP) during organ
transport may increase the safety of “marginal donors.” My colleagues and I investigated …

Purpose Hypothermic machine perfusion of donor hearts enables continuous aerobic
metabolism and washout of toxic metabolic byproducts. We evaluated the effect of machine …

BACKGROUND: Machine perfusion preservation improves reperfusion function of many
solid organs, compared with conventional storage, but has received limited clinical attention …

Background There is a continued interest in ex situ heart perfusion as an alternative strategy
for donor heart preservation. We hypothesize that oxygenated machine perfusion of donor …

The current standard method for organ preservation (cold storage, CS), exposes the heart to
a period of cold ischemia that limits the safe preservation time and increases the risk of …

Background: There has been an increased interest in donation after circulatory death (DCD)
to expand donor pool for cardiac transplantation. Normothermic regional perfusion (NRP) …

Donor hearts cannot be preserved beyond 6 h using cold storage (CS). Improving
preservation methods may permit prolonged storage of donor heart. We compared graft …

Pre-clinical heart transplantation studies have shown that ex vivo non-ischemic heart
preservation (NIHP) can be safely used for 24 h. Here we perform a prospective, open-label …

Cardiac transplantation remains the first choice for the surgical treatment of end stage heart
failure. An inadequate supply of donor grafts that meet existing criteria has limited the …