[HTML][HTML] A naturally occurring carotenoid, lutein, reduces PDGF and H2O2 signaling and compromises migration in cultured vascular smooth muscle cells

HM Lo, YJ Tsai, WY Du, CJ Tsou, WB Wu - Journal of biomedical Science, 2012 - Springer
Background Platelet-derived growth factor (PDGF) is a potent stimulator of growth and
motility of vascular smooth muscle cells (VSMCs). Abnormalities of PDGF/PDGF receptor …

Lycopene binding compromised PDGF-AA/-AB signaling and migration in smooth muscle cells and fibroblasts: prediction of the possible lycopene binding site within …

CP Chen, CF Hung, SC Lee, HM Lo, PH Wu… - … archives of pharmacology, 2010 - Springer
Platelet-derived growth factor (PDGF) is a potent stimulator of growth and motility of smooth
muscle cells (SMCs) and fibroblasts. Abnormalities of PDGF/PDGF receptor (PDGFR) are …

Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells

HM Lo, CF Hung, YL Tseng, BH Chen, JS Jian… - Biochemical …, 2007 - Elsevier
Cardiovascular diseases (CVDs) result from the sub-endothelial accumulation of
inflammatory cells and smooth muscle cells (SMCs). Lycopene, a natural compound from …

Luteolin inhibited hydrogen peroxide-induced vascular smooth muscle cells proliferation and migration by suppressing the Src and Akt signalling pathways

Y Lang, D Chen, D Li, M Zhu, T Xu… - Journal of Pharmacy …, 2012 - academic.oup.com
Objectives Luteolin is a naturally occurring flavonoid found in many vegetables, fruits and
medicinal plants. The migration and proliferation of vascular smooth muscle cells (VSMCs) …

Luteolin prevents PDGF-BB-induced proliferation of vascular smooth muscle cells by inhibition of PDGF β-receptor phosphorylation

JH Kim, YR Jin, BS Park, TJ Kim, SY Kim, Y Lim… - Biochemical …, 2005 - Elsevier
Luteolin occurs as glycosylated forms in celery, green pepper, perilla leaf and camomile tea,
and has been shown to possess antimutagenic, antitumorigenic, antioxidant and …

[HTML][HTML] Inhibitory effects and mechanisms of luteolin on proliferation and migration of vascular smooth muscle cells

D Jiang, D Li, W Wu - Nutrients, 2013 - mdpi.com
Atherosclerosis (AS) is a complicated progress, involving many types of cells. Although the
exact mechanisms of progression of atherosclerosis are uncertain, the balance of vascular …

Luteolin ameliorates hypertensive vascular remodeling through inhibiting the proliferation and migration of vascular smooth muscle cells

J Su, HT Xu, JJ Yu, JL Gao, J Lei, QS Yin… - Evidence‐Based …, 2015 - Wiley Online Library
Objectives. Preliminary researches showed that luteolin was used to treat hypertension.
However, it is still unclear whether luteolin has effect on the hypertensive complication such …

Phloretin Inhibits Platelet-derived Growth Factor-BB–induced Rat Aortic Smooth Muscle Cell Proliferation, Migration, and Neointimal Formation After Carotid Injury

D Wang, Q Wang, G Yan, Y Qiao… - Journal of Cardiovascular …, 2015 - journals.lww.com
Abnormal vascular smooth muscle cell proliferation and migration are key factors in many
cardiovascular diseases. Here, we investigated the effects of phloretin on platelet-derived …

[HTML][HTML] Luteolin inhibits vascular smooth muscle cell proliferation and migration by inhibiting TGFBR1 signaling

YT Wu, L Chen, ZB Tan, HJ Fan, LP Xie… - Frontiers in …, 2018 - frontiersin.org
Vascular smooth muscle cell (VSMC) proliferation and migration play a critical role in the
development of arterial remodeling during various vascular diseases including …

Epigallocatechin-3-gallate inhibits the PDGF-induced VEGF expression in human vascular smooth muscle cells via blocking PDGF receptor and Erk-1/2

JS Park, MH Kim, HJ Chang… - International …, 2006 - spandidos-publications.com
Platelet-derived growth factor (PDGF) has been known to induce vascular endothelial
growth factor (VEGF) expression in human vascular smooth muscle cells (hVSMCs). We …