The aberrant expression of transforming growth factor (TGF)-β1 in the tumor
microenvironment and fibrotic lesions plays a critical role in tumor progression and tissue …

Prolonged deficits in neural input activate pathological muscle remodeling, leading to
atrophy. In denervated muscle, activation of the atrophy program requires HDAC4, a potent …

NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress
response, genome integrity, metabolism and aging, while how it is transcriptionally …

Duchenne muscular dystrophy (DMD) is a life-threatening genetic disease that currently has
no available cure. A number of pharmacological strategies that aim to target events …

HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to
denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially …

Skeletal muscle possesses a high ability to regenerate after an insult or in pathological
conditions, relying on satellite cells, the skeletal muscle stem cells. Satellite cell behavior is …

Histone deacetylase 11 (HDAC11) is the latest identified member of the histone deacetylase
family of enzymes. It is highly expressed in brain, heart, testis, kidney, and skeletal muscle …

Abstract Background Histone deacetylase 4 (HDAC4) has been proposed as a target for
Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction …

Maintenance of skeletal muscle structure and function requires innervation by motor
neurons, such that denervation causes muscle atrophy. We show that myogenin, an …

Transforming growth factor-β (TGF-β) signaling plays a key role in excessive fibrosis. As a
class IIa family histone deacetylase (HDAC), HDAC5 shows a close relationship with TGF-β …