Histone deacetylase 6 (HDAC6) is a cytoplasmic deacetylase that uniquely catalyzes α-
tubulin deacetylation and promotes cell motility. However, the mechanism underlying …

Dysferlin is a multi-C2 domain transmembrane protein involved in a plethora of cellular
functions, most notably in skeletal muscle membrane repair, but also in myogenesis, cellular …

Abstract The NAD+-dependent SIRT1-7 family of protein deacetylases plays a vital role in
various molecular pathways related to stress response, DNA repair, aging and metabolism …

Skeletal muscle atrophy is a severe condition of muscle mass loss. Muscle atrophy is
caused by a down-regulation of protein synthesis and by an increase of protein breakdown …

Neuromuscular disorders are often caused by heterogeneous mutations in large, structurally
complex genes. Targeting compensatory modifier genes could be beneficial to improve …

Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types
which are involved in a great variety of cellular processes. Reversible acetylation on the ϵ …

For the past decade protein acetylation has been shown to be a crucial post-transcriptional
modification involved in the regulation of protein functions. Histone acetyltransferases …

The neuromuscular junction (NMJ), which is a synapse for signal transmission from motor
neurons to muscle cells, has emerged as an important region because of its association with …

Duchenne muscular dystrophy, the most common form of childhood muscular dystrophy, is
caused by X-linked inherited mutations in the dystrophin gene. Dystrophin deficiencies …

Transforming Growth Factor β1 (TGFβ1) is a crucial cytokine triggering myofibroblastic (MF)
differentiation, a process involved in tissue healing as well as in pathologic conditions such …