Neural activity actively regulates muscle gene expression. This regulation is crucial for
specifying muscle functionality and synaptic protein expression. How neural activity is …

Background Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused
by the loss of dystrophin, which results in inflammation, fibrosis, and the inhibition of …

Huntington's disease (HD) is a progressive neurodegenerative disorder for which there is no
effective disease modifying treatment. Following-on from studies in HD animal models …

Duchenne muscular dystrophy (DMD) is a genetic disease characterised by skeletal muscle
degeneration and progressive muscle wasting, which is caused by loss-of-function …

The class IIa histone deacetylases (HDACs) act as transcriptional repressors by altering
chromatin structure through histone deacetylation. This family of enzymes regulates muscle …

Dystrophin is expressed in differentiated myofibers, in which it is required for sarcolemmal
integrity, and loss-of-function mutations in the gene that encodes it result in Duchenne …

Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is an autosomal
recessive disorder caused by mutations in the laminin-α2 gene (OMIM: 607855). Currently …

Molecules that induce ribosomal read-through of nonsense mutations in mRNA and allow
production of a full-length functional protein hold great therapeutic potential for the treatment …

As the complexities of dystrophic pathology have been elucidated over the last few years, it
has become increasingly clear that primary monogenetic defects result in multiple …

Background Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder and
is one of the most common muscular dystrophies. There are currently few effective therapies …