Bone sarcomas are the most common second malignant neoplasms in survivors of a
malignant solid tumor in childhood. In contrast to de novo tumors, secondary bone cancers …

PURPOSE: We analyzed the clinical features and outcome of patients with radiation-
associated osteosarcoma treated during the era of contemporary chemotherapy. PATIENTS …

Background Radiation therapy (RT) confers local tumor control and survival advantages in
some patients with osteosarcoma, yet pediatric and adolescent and young adult (AYA) …

Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This
paper reviews the general management and standard radiotherapy guidelines for …

Involvement of the central nervous system in osteosarcoma is uncommond. These
neoplasms are most often located at the metaphyses of tubular bones and rarely in flat …

A boy, age 2 years 10 months, with high-grade malignant osteosarcoma of the fifth lumbar
vertebra with secondary bilateral pulmonary lesions and bone metastasis at the fifth thoracic …

Three cases of postirradiation osteosarcoma which presented in childhood are reported and
the pertinent literature reviewed. The children had been treated in each instance before the …

PURPOSE AND METHODS Between January 1981 and June 1993, 137 children and
adolescents were each treated at the Institut Gustave Roussy for an initially nonmetastatic …

Osteosarcoma arising in soft tissues is exceedingly rare in children. The tumor most often
affects older adults, involves the lower extremity, responds poorly to chemotherapy, and …

Policies for management of patients with primary osteosarcoma are undergoing rapid
change as a consequence of the demonstrated efficacy of aggressive multidrug-multicycle …