Most common diseases are complex genetic traits, with multiple genetic and environmental
components contributing to susceptibility. It has been proposed that common genetic …

Genetic association studies are used to find candidate genes or genome regions that
contribute to a specific disease by testing for a correlation between disease status and …

The potential of the genetic association approach for the identification of genetic variants
that alter susceptibility to common complex disease is well recognised. 1 This potential …

Association studies offer a potentially powerful approach to identify genetic variants that
influence susceptibility to common disease 1, 2, 3, 4, but are plagued by the impression that …

Association studies with candidate genes have been widely used for the study of complex
diseases. However, this approach has been criticized because of non-replication of results …

With the completion of the human genome project, attention is now rapidly shifting towards
the study of individual genetic variation. The most abundant source of genetic variation in …

Numerous genetic association studies for complex diseases are performed. Investigators
place emphasis on formal statistical significance (P-values< 0.05), but the predictive ability …

Most common diseases and many important quantitative traits are complex genetic traits,
with multiple genetic and environmental variables contributing to the observed phenotype …

Genomewide Association Studies and Human Disease | New England Journal of Medicine Skip
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Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …