Inflammation is the most common feature of many chronic diseases and complications, while
playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 …

Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Oxidative stress has been implicated in the etiology of neurodegenerative disease, cancer
and aging. Indeed, accumulation of reactive oxygen and nitrogen species generated by …

Oxidative stress (OS) is created by an imbalance between reactive oxygen species and
antioxidant levels. OS promotes inflammation and is associated with many diseases, such …

Abstract Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic
stress response and also represses inflammation. However, the mechanisms how Nrf2 …

Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection
against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where …

Significance: Inflammation can be defined as a protective immune response against harmful
exogenous and endogenous stimuli. Nevertheless, prolonged or autoimmune inflammatory …

Nrf2, a redox sensitive transcription factor, plays a pivotal role in redox homeostasis during
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …

Abstract The Keap1‐Nrf2/ARE signaling pathway is an important defense system against
exogenous and endogenous oxidative stress injury. The dysregulation of the signaling …