Neocryptolepine: A promising indoloisoquinoline alkaloid with interesting biological activity. Evaluation of the drug and its most relevant analogs

EL Larghi, A BJ Bracca… - Current Topics in …, 2015 - ingentaconnect.com
Plants are one of the most important resources for the discovery of new drugs. The potential
of natural compounds as new drug leads is clearly illustrated by the discovery and …

Indoloquinolines as scaffolds for drug discovery

J Lavrado, R Moreira, A Paulo - Current medicinal chemistry, 2010 - ingentaconnect.com
Traditional medicines have contributed greatly over the centuries to the discovery and
development of new therapeutic agents and indoloquinoline alkaloids may represent a new …

Bioactivities and synthesis of indoloquinoline alkaloids: cryptolepine, isocryptolepine and neocryptolepine

PT Parvatkar, SG Tilve - 2012 - irgu.unigoa.ac.in
Tetracyclic heteroaromatic compounds with linear or angularly fused indoloquinoline ring
systems constitute an important structural moiety in natural products. The indoloquinoline …

Indoloquinolines: possible biogenesis from common indole precursors and their synthesis using domino strategies

PT Parvatkar, PS Parameswaran - Current Organic Synthesis, 2016 - ingentaconnect.com
The tetracyclic indoloquinoline alkaloids, cryptolepine, neocryptolepine, isocryptolepine and
their analogues, isolated from the West African shrub Cryptolepis sanguinolenta are known …

Structural modifications of nature-inspired indoloquinolines: A mini review of their potential antiproliferative activity

N Wang, M Świtalska, L Wang, E Shaban, MI Hossain… - Molecules, 2019 - mdpi.com
Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline
alkaloids with various spectrum of biological properties. Structural modification is an …

Isolation, biological activities and synthesis of indoloquinoline alkaloids: cryptolepine, isocryptolepine and neocryptolepine

PT Parvatkar, PS Parameswaran… - Current Organic …, 2011 - ingentaconnect.com
The tetracyclic heteroaromatic compounds cryptolepine, isocryptolepine and
neocryptolepine are all naturally occurring indoloquinoline alkaloids isolated from the shrub …

Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives

THM Jonckers, S Van Miert, K Cimanga… - Journal of Medicinal …, 2002 - ACS Publications
On the basis of the original lead neocryptolepine or 5-methyl-5 H-indolo [2, 3-b] quinoline,
an alkaloid from Cryptolepis sanguinolenta, derivatives were prepared using a biradical …

Synthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2, 11-disubstituted indolo [2, 3-b] quinolines

WJ Lu, KJ Wicht, L Wang, K Imai, ZW Mei… - European journal of …, 2013 - Elsevier
This report describes the synthesis, and in vitro and in vivo antimalarial evaluations of
certain ester-modified neocryptolepine (5-methyl-5H-indolo [2, 3-b] quinoline) derivatives …

Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid

EN Thobokholt, EL Larghi, ABJ Bracca, TS Kaufman - RSC advances, 2020 - pubs.rsc.org
Cryptosanguinolentine (isocryptolepine) is one of the minor naturally-occurring monomeric
indoloquinoline alkaloids, isolated from the West African climbing shrub Cryptolepis …

Unravelling the pharmacological properties of cryptolepine and its derivatives: a mini-review insight

CK Tudu, A Bandyopadhyay, M Kumar, Radha… - Naunyn-schmiedeberg's …, 2023 - Springer
Abstract Cryptolepine (1, 5-methyl-10 H-indolo [3, 2-b] quinoline), an indoloquinoline
alkaloid, found in the roots of Cryptolepis sanguinolenta (Lindl.) Schltr (family …