Targeting receptor tyrosine kinase (RTK) degradation may be an interesting approach to
reduce RTK cell signaling in cancer cells. Here we show that increasing E3 ubiquitin ligase …

Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is
needed for proteolytic degradation of CRL substrates, whose accumulation induces cell …

Objective: The E3 ligase, CRL4, plays diverse roles in different cellular processes, such as
DNA damage, transcriptional regulation, cell cycle progression, and cell apoptosis. Our …

The cullin 4 subfamily of genes includes CUL4A and CUL4B, which share a mostly identical
amino acid sequence aside from the elongated N-terminal region in CUL4B. Both act as …

Abstract Cullin-5 (CUL5), a scaffold protein in active cullin-RING ubiquitin ligase (CRL)
complexes, is a member of the cullin family of proteins. The CUL5-type ubiquitin ligase can …

MLN4924 is a recently discovered small molecule inhibitor of NEDD8-Activating Enzyme
(NAE). Because cullin RING ligase (CRL), the largest family of E3 ubiquitin ligase, requires …

Abstract Cullin-RING E3 ligase (CRL) is the largest family of E3 ubiquitin ligase, responsible
for ubiquitylation of∼ 20% of cellular proteins. CRL plays an important role in many …

Hyperactivation of the canonical Wnt-signaling pathway is a prominent feature of a number
of human malignancies. Transcriptional activation of this signaling cascade depends on the …

The ubiquitination–proteasome and degradation system is an essential process that
regulates protein homeostasis. This system is involved in the regulation of cell proliferation …

Background Lung cancer is a malignant tumor with the highest mortality worldwide.
Abnormalities in the ubiquitin proteasome system are considered to be contributed to lung …