Squamous cell carcinoma–related oncogene (SCCRO)/DCUN1D1, a component of the
neddylation E3 complex, regulates the activity of the cullin–RING–ligase type of …

Cullin3 E3 ubiquitin ligase ubiquitinates a wide range of substrates through substrate-
specific adaptors Bric-a-brac, Tramtrack, and Broad complex (BTB) domain proteins. These …

Cullin 4 (CUL 4) and small ring finger protein ROC 1 assemble to form E3 ubiquitin ligase
(CRL 4) complexes. CUL 4 interacts with WD‐40 proteins through the adaptor protein DNA …

Colorectal cancer is one of the leading causes of cancer related deaths worldwide. Cullin 4B
(CUL4B) is over-expressed in diverse cancer types. However, the function and precise …

TP53 deficiency is the most common alteration in cancer; however, this alone is typically
insufficient to drive tumorigenesis. To identify genes promoting tumorigenesis in …

Deregulation of the cell cycle and genome instability are common features of cancer cells
and various mechanisms exist to preserve the integrity of the genome and guard against …

Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a
neddylated cullin-RING catalytic module and a variable substrate-binding receptor (for …

Abstract Cullin (CUL)-RING E3 ubiquitin ligases (CRLs) are attractive therapeutic targets as
they regulate diverse biological processes important for cancer cell survival by conferring …

Neddylation is a post-translational protein modification process associated with
carcinogenesis and cancer development. MLN4924, a pharmaceutical neddylation inhibitor …

Cereblon (CRBN) is the substrate receptor of the cullin 4-RING E3 ligase complex and has
been employed for targeted protein degradation in the treatment of cancers. However, its …