Higher order organization of the mtDNA: beyond mitochondrial transcription factor A
The higher order organization of eukaryotic and prokaryotic genomes is pivotal in the
regulation of gene expression. Specifically, chromatin accessibility in eukaryotes and …
regulation of gene expression. Specifically, chromatin accessibility in eukaryotes and …
mtDNA chromatin-like organization is gradually established during mammalian embryogenesis
Unlike the nuclear genome, the mammalian mitochondrial genome (mtDNA) is thought to be
coated solely by mitochondrial transcription factor A (TFAM), whose binding sequence …
coated solely by mitochondrial transcription factor A (TFAM), whose binding sequence …
A common pattern of DNase I footprinting throughout the human mtDNA unveils clues for a chromatin-like organization
Human mitochondrial DNA (mtDNA) is believed to lack chromatin and histones. Instead, it is
coated solely by the transcription factor TFAM. We asked whether mtDNA packaging is more …
coated solely by the transcription factor TFAM. We asked whether mtDNA packaging is more …
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA
Cellular metabolism relies on the regulation and maintenance of mitochondrial DNA
(mtDNA). Hundreds to thousands of copies of mtDNA exist in each cell, yet because …
(mtDNA). Hundreds to thousands of copies of mtDNA exist in each cell, yet because …
TFAM forces mtDNA to make a U-turn
BM Hallberg, NG Larsson - Nature structural & molecular biology, 2011 - nature.com
The mammalian mitochondrial transcription factor A (TFAM) is encoded in the nucleus and
imported into mitochondria, where it functions as an activator of mtDNA transcription and …
imported into mitochondria, where it functions as an activator of mtDNA transcription and …
Genome-wide analysis reveals coating of the mitochondrial genome by TFAM
YE Wang, GK Marinov, BJ Wold, DC Chan - PloS one, 2013 - journals.plos.org
Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as
mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids …
mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids …
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation
Mitochondria, the only semiautonomous organelles in mammalian cells, possess a circular,
double-stranded genome termed mitochondrial DNA (mtDNA). While nuclear genomic DNA …
double-stranded genome termed mitochondrial DNA (mtDNA). While nuclear genomic DNA …
Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution
Mitochondrial DNA (mtDNA) genes are long known to be cotranscribed in polycistrones, yet
it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing …
it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing …
Transcription factors bind negatively selected sites within human mtDNA genes
Transcription of mitochondrial DNA (mtDNA)-encoded genes is thought to be regulated by a
handful of dedicated transcription factors (TFs), suggesting that mtDNA genes are separately …
handful of dedicated transcription factors (TFs), suggesting that mtDNA genes are separately …
Functional complementation of mitochondrial DNAs: mobilizing mitochondrial genetics against dysfunction
EA Schon, RW Gilkerson - Biochimica et Biophysica Acta (BBA)-General …, 2010 - Elsevier
Human mitochondrial DNA (mtDNA) is a 16.6-kb circular genome that is typically found in∼
1000 copies per cell. Frequently, one or more forms of mtDNA (ie wildtype (WT) and one or …
1000 copies per cell. Frequently, one or more forms of mtDNA (ie wildtype (WT) and one or …
相关搜索
- mitochondrial dna transcription factor
- mtdna genes transcription factors
- cell types mtdna transcription
- mitochondrial dna heterogeneous packaging
- functional complementation mitochondrial dnas
- mitochondrial dna cpg sequences
- mitochondrial dna cytosine methylation
- transcription factor cpg sequences
- transcription factor cytosine methylation