Tight regulation of luteinizing hormone-β subunit (LHβ) expression is critical for
differentiation and maturation of mammalian sexual organs and reproductive function. Two …

We have previously shown that early growth response (Egr) 1-deficient mice exhibit female
infertility, reflecting a luteinizing hormone (LH) β deficiency. Egr-1 activates the LHβ gene in …

Recently, several cis-regulatory elements that play roles in LHβ gene expression, and their
cognate DNA-binding transcription factors, have been identified. These factors include Sp1 …

Recent in vivo and in vitro studies have implicated the orphan nuclear receptor,
steroidogenic factor-1 (SF-1), and the early growth response protein 1 (Egr-1) in the …

LH and FSH play critical roles in mammalian reproduction by mediating steroidogenesis and
gametogenesis in the gonad. Gonadal steroid hormone feedback to the hypothalamus and …

Expression of the LHβ gene has been shown to be modulated by both the orphan nuclear
receptor, steroidogenic factor-1 (SF-1), and the early growth response protein 1, Egr-1. It is …

Activation of the luteinizing hormone β (LHβ) promoter by gonadotropin-releasing hormone
(GnRH) via the transcription factor early growth response protein-1 (Egr1) has been well …

Abstract Gonadotrophin-releasing hormone (GNRH1) regulates pituitary luteinizing
hormone (LH). Previous studies have delineated a mechanism for GNRH1-induced LHβ …

Pituitary gonadotropins are critical regulators of gonadal development and function.
Expression and secretion of the mature hormones are regulated by gonadotropin-releasing …

Transcription of the LH subunit genes is stimulated by GnRH and may be modulated
physiologically by steroids such as 17β-estradiol (E). We found that E treatment amplified …