Nasal immunization of mice with human papillomavirus type 16 (HPV-16) virus-like particles or with the HPV-16 L1 gene elicits specific cytotoxic T lymphocytes in …

C Dupuy, D Buzoni-Gatel, A Touzé, D Bout… - Journal of …, 1999 - Am Soc Microbiol
ABSTRACT Human papillomavirus type 16 (HPV-16) infects the genital tract and is closely
associated with the development of cervical cancer. HPV-16 initiates infection at the genital …

Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions

C Balmelli, R Roden, A Potts, J Schiller… - Journal of …, 1998 - Am Soc Microbiol
To specifically induce a mucosal antibody response to purified human papillomavirus type
16 (HPV16) virus-like particles (VLP), we immunized female BALB/c mice orally …

Cellular immune responses to human papillomavirus (HPV)-16 L1 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles

LA Pinto, J Edwards, PE Castle… - The Journal of …, 2003 - academic.oup.com
The causal association between papillomavirus (HPV) infection and cervical cancer has
been demonstrated; the development of a prophylactic vaccine to protect against HPV …

Mucosal vaccination with a recombinant Salmonella typhimurium expressing human papillomavirus type 16 (HPV16) L1 virus-like particles (VLPs) or HPV16 VLPs …

V Revaz, J Benyacoub, WM Kast, JT Schiller… - Virology, 2001 - Elsevier
Human papillomaviruses, mainly type 16 (HPV16), are responsible for cervical
intraepithelial neoplasia, which can lead, in association with other factors, to cervical cancer …

Humoral and cellular immune responses to airway immunization of mice with human papillomavirus type 16 virus-like particles and mucosal adjuvants

V Revaz, R Zurbriggen, C Moser, JT Schiller, F Ponci… - Antiviral research, 2007 - Elsevier
Cervical cancer results from cervical infection by human papillomaviruses (HPV), especially
HPV16. Intramuscular administrations of HPV16 virus-like particle (VLP) vaccines have …

Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles

D Fraillery, N Zosso, D Nardelli-Haefliger - Vaccine, 2009 - Elsevier
Human papillomavirus (HPV) vaccines based on L1 virus-like particle (VLP) can prevent
genital HPV infection and associated lesions after three intramuscular injections. Needle …

[HTML][HTML] Oral immunization with different assembly forms of the HPV 16 major capsid protein L1 induces neutralizing antibodies and cytotoxic T-lymphocytes

N Thönes, M Müller - Virology, 2007 - Elsevier
Human papillomaviruses have been recognized as the causative agent of anogenital
cancer. In 2006, a commercial vaccine based on virus-like particles composed of the L1 …

Mucosal but not parenteral immunization with purified human papillomavirus type 16 virus-like particles induces neutralizing titers of antibodies throughout the estrous …

D Nardelli-Haefliger, R Roden, C Balmelli… - Journal of …, 1999 - Am Soc Microbiol
We have recently shown that nasal immunization of anesthetized mice with human
papillomavirus type 16 (HPV16) virus-like particles (VLPs) is highly effective at inducing both …

Trachea, lung, and tracheobronchial lymph nodes are the major sites where antigen-presenting cells are detected after nasal vaccination of mice with human …

C Balmelli, S Demotz, H Acha-Orbea… - Journal of …, 2002 - Am Soc Microbiol
Vaccination by the nasal route has been successfully used for the induction of immune
responses. Either the nasal-associated lymphoid tissue (NALT), the bronchus-associated …

Cell mediated immunity induced in mice by HPV 16 L1 virus-like particles

C Dupuy, D Buzoni-Gate, A Touze, P Le Cann… - Microbial …, 1997 - Elsevier
Recombinant human papillomavirus (HPV) type 16 L1 virus-like particles (VLPs) expressed
in the baculovirus system were used to investigate the cellular immune response to human …