In this study, we evaluated the effects of protopanaxadiol (PPD), a gut microbiome induced
ginseng metabolite, in increasing the anticancer effects of a chemotherapeutic agent …

Natural products play an important role in cancer therapeutics, and lately more attentions
have been paid to the prevention of major lethal malignancies, such as colorectal cancer …

Purpose Colorectal cancer is a major cause of morbidity and mortality for cancer worldwide.
Although 5-fluorouracil (5-FU) is one of the most widely used chemotherapeutic agents in …

Introduction As a commonly used chemotherapeutic agent, fluorouracil (5-FU) has serious
dose-limiting side effects. In this study, we evaluated the synergy between red American …

Compound K (20-O-beta-d-glucopyranosyl-20 (S)-protopanaxadiol, CK), an intestinal
bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to inhibit cell …

Previous studies showed that Asian ginseng, Panax ginseng CA Meyer, may have anti-
cancer properties. However, there is limited data exploring the use of Asian ginseng as an …

Chemotherapy is one of the most commonly used treatments for patients with advanced
colon cancer, yet the toxicity of chemotherapy agents, such as 5‑fluorouracil (5‑FU), limits …

Protopanaxadiol (PPD), a ginseng metabolite generated by the gut bacteria, was shown to
induce colorectal cancer cell death and enhance the anticancer effect of chemotherapeutic …

Plant-derived active constituents and their semi-synthetic or synthetic analogs have served
as major sources of anticancer drugs. 20 (S)-protopanaxadiol (PPD) is a metabolite of …

Ginsenoside compound K (CK) is an intestinal microbiota metabolite of ginsenoside Rb1, a
major constituent in American ginseng. However, previous ginseng anti-cancer observations …