Background Glial cell activation and overproduction of inflammatory mediators in the central
nervous system (CNS) have been implicated in acute traumatic injuries to the CNS …

Simple Summary The neuroinflammatory response is a rather complex event in spinal cord
injury (SCI) and has the capacity to exacerbate cell damage but also to contribute to the …

Pre-clinical studies place tumor necrosis factor (TNF) as a central player in the inflammatory
response after spinal cord injury (SCI), and blocking its production and/or activity has been …

Spinal cord injury (SCI) results in immediate damage followed by a secondary phase of
tissue damage that occurs over a period of several weeks. The mechanisms underlying this …

Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Background The infliction of a traumatic spinal cord injury (SCI) propagates damage that
occurs in 2 stages. The first phase of trauma develops from the initial mechanical insult. The …

Background The acute phase response (APR) to CNS insults contributes to the overall
magnitude and nature of the systemic inflammatory response. Aspects of this response are …

Spinal cord injury (SCI) leads to irreversible devastating neurological disabilities.
Accumulated evidence in the literature indicates that the inflammatory response that occurs …

Posttraumatic inflammatory reaction may contribute to secondary injury after traumatic spinal
cord injury (SCI). Expression of tumor necrosis factor-α (TNF-α), a key inflammatory …

Many therapies that have been developed for acute spinal cord injury (SCI) either influence
or are influenced by posttraumatic inflammation. Many such therapies have reportedly …