Oxidative imbalance is a prominent feature in Alzheimer's disease and ageing. Increased
levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to …

Alzheimer's disease (AD), certainly the most widespread proteinopathy, has as classical
neuropathological hallmarks, two groups of protein aggregates: senile plaques and …

Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading
cause of dementia, imposing a growing economic burden upon society. The disease …

Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by the accumulation of amyloid β peptide (Aβ). Although most AD mouse …

The urea cycle is strongly implicated in the pathogenesis of Alzheimer's disease (AD).
Arginase-I (ARGI) accumulation at sites of amyloid-beta (Aβ) deposition is associated with L …

Levels of nicotinamide adenine dinucleotide (NAD+) are known to decline with age and
have been associated with impaired mitochondrial function leading to neurodegeneration, a …

Early cognitive deficits in Alzheimer's disease (AD) seem to be correlated to dysregulation of
glutamate receptors evoked by amyloid-beta (Aβ) peptide. Aβ interference with the activity of …

Synapses are sites of high energy demand which are dependent on high levels of
mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are …

Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis
and induces neuropathological changes, such as impaired neuronal integrity …

The pathogenesis of Alzheimer's disease (AD), the most prevalent form of dementia,
remains unclear. Over the past few years, evidence has accumulated indicating that …