Amyloid-β (Aβ) peptide-binding alcohol dehydrogenase (ABAD), an enzyme present in
neuronal mitochondria, exacerbates Aβ-induced cell stress. The interaction of ABAD with Aβ …

The complexities that underlie the cognitive impairment and neurodegeneration
characteristic of Alzheimer's disease (AD) have yet to be completely understood, although …

The common feature of urea cycle diseases (UCD) is a defect in ammonium elimination in
liver, leading to hyperammonemia. This excess of circulating ammonium eventually reaches …

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability,
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …

Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in
Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD …

Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

Emerging findings suggest that compromised cellular bioenergetics and DNA repair
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …

Alzheimer's disease (AD) is a conformational disease that is characterized by amyloid-β (Aβ)
deposition in the brain. Aβ exerts its toxicity in part by receptor-mediated interactions that …

Mitochondrial aberrations are observed in human Alzheimer's disease (AD) and in medical
conditions that increase the risk of this disorder, suggesting that mitochondrial dysfunction …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …