The genetics of inflammatory bowel disease
DK Bonen, JH Cho - Gastroenterology, 2003 - Elsevier
The inflammatory bowel diseases (IBD) comprise complex genetic disorders, with multiple
contributing genes. Linkage studies have implicated several genomic regions as likely …
contributing genes. Linkage studies have implicated several genomic regions as likely …
Genetics of inflammatory bowel disease: progress and prospects
CG Mathew, CM Lewis - Human molecular genetics, 2004 - academic.oup.com
Strong epidemiological evidence for a genetic contribution to pathogenesis in inflammatory
bowel disease (IBD) has stimulated efforts to identify susceptibility genes for both of its major …
bowel disease (IBD) has stimulated efforts to identify susceptibility genes for both of its major …
Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease
The identification of the role of genetic variants within NOD2 (CARD15) in Crohn's disease
and ulcerative colitis susceptibility highlight the role of the innate immune system in …
and ulcerative colitis susceptibility highlight the role of the innate immune system in …
Inflammatory bowel disease genetics: Nod2
JH Cho, C Abraham - Annu. Rev. Med., 2007 - annualreviews.org
The inflammatory bowel diseases (IBD) are comprised of two major subphenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). A significant role for genetic factors in IBD was …
disease (CD) and ulcerative colitis (UC). A significant role for genetic factors in IBD was …
Update on the genetics of inflammatory bowel disease
RH Duerr - Journal of clinical gastroenterology, 2003 - journals.lww.com
There is a general consensus that interplay of genetic and environmental factors leads to an
overactive mucosal immune response, which mediates the tissue damage in inflammatory …
overactive mucosal immune response, which mediates the tissue damage in inflammatory …
The genetics of inflammatory bowel disease
J Van Limbergen, RK Russell, ER Nimmo… - Official journal of the …, 2007 - journals.lww.com
Great progress in the understanding of the molecular genetics of inflammatory bowel
disease (IBD) has been made over the last 10 years. Strong epidemiological evidence …
disease (IBD) has been made over the last 10 years. Strong epidemiological evidence …
Novel pathophysiological concepts of inflammatory bowel disease
T Hibi, H Ogata - Journal of gastroenterology, 2006 - Springer
The search for susceptibility genes had its first success in 1996, when the first susceptibility
locus for CD was identified in the pericentromeric region of chromosome 16, which was …
locus for CD was identified in the pericentromeric region of chromosome 16, which was …
The genetic basis of inflammatory bowel disease
R Cooney, D Jewell - Digestive diseases, 2009 - karger.com
Twin studies and large-scale population studies have confirmed an increased sibling risk for
both Crohn's disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and …
both Crohn's disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and …
[HTML][HTML] Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered …
PL Lakatos, S Fischer, L Lakatos, I Gal… - World Journal of …, 2006 - ncbi.nlm.nih.gov
The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various
environmental and host (eg genetic-, epithelial-, immune and non-immune) factors are …
environmental and host (eg genetic-, epithelial-, immune and non-immune) factors are …
Inflammatory bowel disease: genetics, epigenetics, and pathogenesis
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …