Both, the decreased L-type Ca2+ current (ICa, L) density and increased spontaneous Ca2+
release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation …

Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Efforts to identify the mechanisms for the initiation and maintenance of human atrial
fibrillation (AF) often focus on changes in specific elements of the atrial “substrate,” ie, its …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …

Atrial fibrillation (AF) is characterized by sustained high atrial activation rates and
arrhythmogenic cellular Ca2+ signaling instability; however, it is not clear how a high atrial …

Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …

Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …

Atrial Fibrillation: From Cell to Bedside. Atrial fibrillation is the most common sustained
tachyarrhythmia and, as such, has become the recent focus of intense clinical and …

Atrial fibrillation (AF) is the most common cardiac arrhythmia with a substantial impact on
morbidity and mortality. Antiarrhythmic drugs play a major role in rhythm-control therapy of …

Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …