Atrial fibrillation is a complex arrhythmia with multiple possible mechanisms. A lot of
experimental and clinical studies have shed light on the pathophysiological mechanisms of …

Atrial fibrillation (AF) is the most common sustained arrhythmia disease. Current drug-and
surgical-based therapies are ineffective in about 40% to 50% of AF patients; therefore, there …

Recent clinical studies performed in human subjects have provided important clues that
improved our understanding of the mechanisms of atrial fibrillation (AF) and facilitated …

Recent advances in our understanding of the mechanisms underlying atrial fibrillation (AF)
have further underscored the complex pathophysiological basis of the arrhythmia. It has …

Atrial fibrillation (AF) is the most common sustained arrhythmia. It is associated with a
markedly increased risk of premature death due to embolic stroke and also complicates co …

The initial hypotheses on AF pathogenesis date back to the early 1900s when the two main
theories of focal activity and multiple reentry circuits were proposed. Despite extensive …

Over the past several years, there has been increasing interest in understanding the basic
mechanisms underlying atrial fibrillation (AF). The rise in interest is partly related to the …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, largely associated to morbidity
and mortality. Over the past decades, research in appearance and progression of this …

Cardiac arrhythmias remain a common challenge and are associated with significant
morbidity and mortality. Effective and safe rhythm control strategies are a primary, yet unmet …

Shortened action-potential duration (APD) and blunted APD rate adaptation are hallmarks of
chronic atrial fibrillation (cAF). Basal and muscarinic (M)-receptor-activated inward-rectifier …