[HTML][HTML] Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): A current overview of active targeting in brain diseases

MI Teixeira, CM Lopes, MH Amaral, PC Costa - Colloids and Surfaces B …, 2023 - Elsevier
The blood-brain barrier (BBB) restricts the access of therapeutic agents to the brain,
complicating the treatment of neurological diseases, such as Alzheimer's disease (AD) …

Lipid-based nanocarriers for neurological disorders: a review of the state-of-the-art and therapeutic success to date

BA Witika, MS Poka, PH Demana, SK Matafwali… - Pharmaceutics, 2022 - mdpi.com
Neurodegenerative disorders including Alzheimer's, Parkinson's, and dementia are chronic
and advanced diseases that are associated with loss of neurons and other related …

Engineered solid lipid nanoparticles and nanostructured lipid carriers as new generations of blood–brain barrier transmitters

M Amiri, S Jafari, M Kurd, H Mohamadpour… - ACS Chemical …, 2021 - ACS Publications
The blood–brain barrier (BBB) is considered as the most challenging barrier in brain drug
delivery. Indeed, there is a definite link between the BBB integrity defects and central …

The battle of lipid-based nanocarriers against blood-brain barrier: A critical review

KK Abla, MM Mehanna - Journal of Drug Targeting, 2023 - Taylor & Francis
Central nervous system integrity is the state of brain functioning across sensory, cognitive,
emotional-social behaviors, and motor domains, allowing a person to realise his full …

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
In last two decades, the lipid nanocarriers have been extensively investigated for their drug
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …

Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases

MI Teixeira, CM Lopes, MH Amaral, PC Costa - European journal of …, 2020 - Elsevier
The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

Lipid-based nanocarriers for CNS-targeted drug delivery

MR Micheli, R Bova, A Magini… - Recent Patents on …, 2012 - ingentaconnect.com
Nanotechnology exerts an increasing impact on the development of more effective tools for
the diagnosis and treatment of human diseases. This applies in particular to central nervous …

Lipid nanocarriers for neurotherapeutics: introduction, challenges, blood-brain barrier, and promises of delivery approaches

M Aslam, MN Javed, HH Deeb… - CNS & Neurological …, 2022 - ingentaconnect.com
Significant efforts have been made in research to discover newer neurotherapeutics,
however, the rate of reported neurological disorders has been increasing at an alarming …

Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

C Tapeinos, M Battaglini, G Ciofani - Journal of Controlled Release, 2017 - Elsevier
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a
category of versatile drug delivery systems that have been used in the biomedical field for> …

Recent progress of drug nanoformulations targeting to brain

AR Khan, X Yang, M Fu, G Zhai - Journal of Controlled Release, 2018 - Elsevier
Most of the potential therapeutic agents capable to modulate the pathophysiology or treat
the neurological disorders and brain tumors are useless in the current modern and …